In VitroandIn VivoEffects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum
نویسندگان
چکیده
منابع مشابه
Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection.
Toxoplasma gondii is a unicellular parasite that causes severe brain and eye disease. Current drugs for T. gondii are limited by toxicity. Bumped kinase inhibitors (BKIs) selectively inhibit calcium-dependent protein kinases of the apicomplexan pathogens T. gondii, cryptosporidia, and plasmodia. A lead anti-Toxoplasma BKI, 1294, has been developed to be metabolically stable and orally bioavaila...
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Neospora caninum (N. caninum) and Toxoplasma gondii (T. gondii) are both obligate intracellular protozoan parasites, which have gained considerable attention because of their role in bovine abortion. This study aimed to detect anti-N. caninum and -T. gondii in bulk milk of dairy cattle, Mashhad, Iran. The bulk milk samples were collected from July 2014 to June 2015 and analyzed for anti-N. cani...
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Introduction Toxoplasma gondii and the closely related Neospora caninum are important obligate intracellular apicomplexan parasites causing a wide range of diseases in different host species. Their life cycles are similar, consisting of a) asexual stage where multiplying tachyzoites trigger lesion development in different tissues and eventually develops to persistent tissue cysts in intermediat...
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15 صفحه اولSeroprevalence and Risk Factors of Neospora caninum and Toxoplasma gondii in Small Ruminants in Southwest of Iran
Toxoplasma gondii and Neospora caninum are Apicomplexan intracellular protozoa with global distribution. Small ruminants play an important role as intermediate hosts for N. caninum and T. gondii, parasites of great public health concern. The main goal of the current survey was to evaluate N. caninum and T. gondii infection rate in sheep and goats of Khuzestan Province, southwest of Iran, using ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2015
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01236-15